Student written Research Laboratory Guidebook 2022

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Stem Cell Engineering Laboratory

Associate Professor / Kiyoshi OHNUMA

Associate ProfessorKiyoshi OHNUMA

profiles and activiities profiles and activiities at nagaoka university of technology
  • Contribute to regenerative medicine
  • Balancing reserch and part-time work
  • Elucidation of the mechanism of human embryogenesis


Associate Professor / Kiyoshi OHNUMA
Our teacher thinks about student's futures carefully.
Although he is very busy with research and education, he frequently listens to us and thinks about our studies and careers together.
Our teacher's advice is based on what he has learned from experiences in Japan and abroad, so we can learn a lot.

Research Content

Our research's overall goal is to understand the cellular level
dynamics of human embryos and develop a microfluidic system for
testing drug safety for the fetus.
We utilize human induced pluripotent stem (iPS) cells to tackle this issue.
1: Single-cell analysis of cell migration to understand morphogenesis
2: Development of microfluidic to culture human iPS cells
3: Effects of teratogenic drugs on human embryo
4: Planarian cell culture for understanding regeneration dynamics

A Day in the Lab

1. Laboratory timetable: The laboratory starts at 9:30 in the morning. Everyone in the lab will discuss about daily acience news and report the schedule for that day. After the morning meeting, we are free to do our planned experiments. We report experimental progress once a week, etc.
2. Atmosphere of laboratory: Since overyone gathers on weekdays, all students can be familiar with each other. We do the experiment while help each other, and we also have a chat.
3. Extracurricular activity: We will go out for lunch to celebrate the member's birthday, for cherry blossoms and Nagaoka fireworks, etc.

Group photo of laboratory members

Thesis Subjects

  • (M)High cell density suppresses BMP4-induced differentiation of human pluripotent stem cells to produce macroscopic spatial patterning in an unidirectional perfusion culture chamber
  • (D)Cardiac differentiation at an initial low density of human-induced pluripotent stem cells
  • (D)Thalidomide induces apoptosis during early mesodermal differentiation of human induced pluripotent stem cells

The number of
PhD Graduates


Major employers of Graduates

  • VSN, Inc.
  • Aleph-inc.
  • Shinshin Pharmaceutical Co.,Ltd.
  • Kobayashi Pharmaceutical Co., Ltd.
  • Nipponham Delicatessen Ltd.
  • Try Angle, Inc.
  • WDB Eureka Co., Ltd.
  • Nippi, Inc.
  • iCeMS Kyoto University
Writer : Bioengneering KISHI Yuta
(National Institute of Technology, Oyama College)