Proteins have different functions and stability depending on their structure (type, order, interaction) of amino acids, and play various roles in the living body. Our laboratory aims to establish technology for designing and developing new proteins with higher function and/or stability than natural proteins. Currently, we are focusing on evaluation and molecular design of the physical properties of industorial enzymes and a single-stranded DNA-binding proteins by making full use of a high-precision differential scanning calorimeter (DSC) and spectrometer.