Our laboratory studies separation chemistry and radiochemical analysis for complex, multicomponent systems. We design and evaluate functional materials—tailored polymer resins, silica-supported adsorbents, layered oxides, and functionalized Metal Organic Frameworks (MOFs)—to achieve selective uptake and reliable column performance. Mechanistic insight is developed through batch and chromatographic experiments across realistic solution conditions, supported by quantitative elemental determination using inductively coupled plasma–mass spectrometry (ICP-MS) and appropriate radiation detection. We also pursue process-oriented technologies, including electrodialysis and target fabrication/dissolution workflows, aiming to translate laboratory results into practical separation, waste-management, and radioisotope production strategies.